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Article

Association of common gene variants in the WNT/β-catenin pathway with colon cancer recurrence.

The pharmacogenomics journal - 1 Apr 2014

Páez D, Gerger A, Zhang W, Yang D, Labonte M J, Benhanim L, Kahn M, Lenz F, Lenz C, Ning Y, Wakatsuki T, Loupakis F, Lenz H-J

Abstract excerpt

Wnt/β-catenin signaling has a central role in the development and progression of most colon cancers (CCs). Germline variants in Wnt/β-catenin pathway genes may result in altered gene function and/or activity, thereby causing inter-individual differences in relation to tumor recurrence capacity and chemoresistance. We investigated germline polymorphisms in a comprehensive panel of Wnt/β-catenin pathway genes to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23817222
DOI: 10.1038/tpj.2013.20

Genes

TTR
APC
CXXC4
DKK2
DKK3
GLI1
NOTCH2
SFRP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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