Article
Genetic interaction analysis of TCF7L2 for biochemical recurrence after radical prostatectomy in localized prostate cancer.
International journal of medical sciences - 1 Jan 2015
Chen Chien-Shu, Huang Chao-Yuan, Huang Shu-Pin, Lin Victor C, Yu Chia-Cheng, Chang Ta-Yuan, Bao Bo-Ying
Abstract excerpt
UNLABELLED: Backgroud: Accumulated evidence has demonstrated a significant role of the Wnt pathway in human prostate cancer. We hypothesize that genetic variants in the Wnt pathway effector, Transcription factor 7-like 2 (TCF7L2), may influence clinical outcomes in prostate cancer. METHODS: We comprehensively selected 12 tagged single-nucleotide polymorphisms (SNPs) to capture majority of common variants across...
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