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Article

APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers.

Genes, chromosomes & cancer - 1 May 2002

Gerstein Amy V, Almeida Teresa Acosta, Zhao Guojing, Chess Eric, Shih Ie-Ming, Buhler Kent, Pienta Kenneth, Rubin Mark A, Vessella Robert, Papadopoulos Nickolas

Abstract excerpt

Genetic alterations serve as beacons for the involvement of specific pathways in tumorigenesis. It was previously shown that 5% of prostate tumors harbor CTNNB1 mutations, suggesting that this tumor type may involve a deregulated APC/CTNNB1 pathway. To explore this possibility further, we searched for mutations in genes implicated in this pathway in 22 samples that included cell lines, xenografts, and primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11921277
DOI: 10.1002/gcc.10037

Genes

CTNNB1
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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