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Article

Characterization of Wnt Signaling Pathway Aberrations in Metastatic Prostate Cancer.

Molecular cancer research : MCR - 2 Oct 2024

Choi Sharon H, Pan Elizabeth, Elliott Andrew, Beltran Himisha, Panian Justine, Jamieson Christina, Bagrodia Aditya, Rose Brent, Herchenhorn Daniel, Heath Elisabeth, Nabhan Chadi, Antonarakis Emmanuel S, McKay Rana R

Abstract excerpt

Wnt (wingless-type) signaling pathway (WSP) alterations have been identified in patients with prostate cancer and are implicated in disease progression and hormonal resistance. In this study, we utilized a multi-institutional dataset to characterize molecular alterations in the canonical and noncanonical WSPs in prostate cancer. Patients with prostate cancer who underwent tissue-based genomic sequencing were...

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PMID: 38912907
DOI: 10.1158/1541-7786.MCR-24-0395

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