Article
Clinical significance of tumor necrosis factor receptor superfamily member 11b polymorphism in prostate cancer.
Annals of surgical oncology - 1 Jun 2010
Bao Bo-Ying, Lin Victor C, Huang Shu-Hung, Pao Jiunn-Bey, Chang Ta-Yuan, Lu Te-Ling, Lan Yu-Hsuan, Chen Lu-Min, Ting Wen-Chien, Yang Wen-Hui, Hsieh Chi-Jeng, Huang Shu-Pin
Abstract excerpt
BACKGROUND: Bone metastases are the most critical complication of prostate cancer (PCa), resulting in severe morbidity and mortality. Tumor necrosis factor receptor superfamily member 11b (TNFRSF11B) is a critical regulator between PCa cells and the bone environment. Recently, TNFRSF11B rs10505346 has been implicated in PCa risk in the Cancer Genetic Markers of Susceptibility genomewide association study....
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