Article
WNT Pathway Mutations in Metachronous Oligometastatic Castration-Sensitive Prostate Cancer.
International journal of radiation oncology, biology, physics - 1 Apr 2023
Sutera Philip, Deek Matthew P, Van der Eecken Kim, Shetty Amol C, Chang Jin Hee, Hodges Theresa, Song Yang, Verbeke Sofie, Van Dorpe Jo, Fonteyne Valérie, De Laere Bram, Mishra Mark, Rana Zaker, Molitoris Jason, Ferris Matthew, Ross Ashley, Schaeffer Edward, Roberts Nicholas, Song Daniel Y, DeWeese Theodore, Pienta Kenneth J, Antonarakis Emmanuel S, Ost Piet, Tran Phuoc T
Abstract excerpt
PURPOSE: WNT signaling is a cellular pathway that has been implicated in the development and progression of prostate cancer. Oligometastatic castration-sensitive prostate cancer (omCSPC) represents a unique state of disease in which metastasis-directed therapy (MDT) has demonstrated improvement in progression-free survival. Herein, we investigate the clinical implications of genomic alterations in the WNT...
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