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Article

Clinical implications of Wnt pathway genetic alterations in men with advanced prostate cancer.

Prostate cancer and prostatic diseases - 1 Jun 2025

Broderick Amanda, Pan Elizabeth, Li Jinju, Chu Alec, Hwang Clara, Barata Pedro C, Cackowski Frank Cameron, Labriola Matthew, Ghose Alyssa, Bilen Mehmet Asim, Kilari Deepak, Thapa Bicky, Piero Michael, Graham Laura, Tripathi Abhishek, Garje Rohan, Koshkin Vadim S, Hernandez Erik, Dorff Tanya B, Schweizer Michael Thomas, Alva Ajjai Shivaram, McKay Rana R, Armstrong Andrew J

Abstract excerpt

BACKGROUND: Aberrant Wnt signaling has been implicated in prostate cancer tumorigenesis and metastasis in preclinical models but the impact of genetic alterations in Wnt signaling genes in men with advanced prostate cancer is unknown. METHODS: We utilized the Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort (PROMISE) clinical-genomic database for this retrospective analysis. Patients...

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Source

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Identifiers

PMID: 39019980
DOI: 10.1038/s41391-024-00869-1
PMCID: PMC11739431

Genes

AR
FOXA1
PIK3CA
RB1
SPOP
APC
CTNNB1
RNF43
RSPO2
ZNRF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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