Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients.

doi:10.1111/j.1523-5378.2009.00712.x

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Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients.

Helicobacter - 1 Oct 2009

Wang Xiaoyong, Yang Jing, Ho Bo, Yang Yang, Huang Zuhu, Zhang Zhihong, Zhang Guoxin

Abstract excerpt

BACKGROUND AND AIMS: MDM2 is a major negative regulator of p53, and a single nucleotide polymorphism (SNP) in the MDM2 promoter region SNP309 (rs2279744) has been shown to increase the affinity of the transcriptional activator Sp1, resulting in elevated MDM2 transcription and expression in some cancers. The aim of this study was to determine whether SNP309 is associated with susceptibility to gastric cancer in...

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PMID: 19751436
DOI: 10.1111/j.1523-5378.2009.00712.x

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients.PMID 19751436Read ↗

Helicobacter pylori infection and MDM2 SNP309 association with gastric cancer susceptibility.Semantic proximity Read ↗

MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis.Semantic proximity Read ↗

Association between MDM2 SNP309 T>G and risk of gastric cancer: a meta-analysis.Semantic proximity Read ↗

Meta-analysis of the MDM2 T309G polymorphism and gastric cancer risk.Semantic proximity Read ↗

Genetic Polymorphism of MDM2 SNP309 in Patients with Helicobacter Pylori-Associated Gastritis.Semantic proximity Read ↗

A functional polymorphism T309G in MDM2 gene promoter, intensified by Helicobacter pylori lipopolysaccharide, is associated with both an increased susceptibility and poor prognosis of gastric carcinoma in Chinese patients.Semantic proximity Read ↗

MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis.Semantic proximity Read ↗

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MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis.Semantic proximity Read ↗

No association of MDM2 T309G polymorphism with susceptibility to Korean gastric cancer patients.Semantic proximity Read ↗

Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk.Semantic proximity Read ↗

MDM2 SNP309 polymorphism is associated with colorectal cancer risk.Semantic proximity Read ↗

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