Article
A functional polymorphism T309G in MDM2 gene promoter, intensified by Helicobacter pylori lipopolysaccharide, is associated with both an increased susceptibility and poor prognosis of gastric carcinoma in Chinese patients.
BMC cancer - 18 Mar 2013
Pan Xiaolin, Li Yuqin, Feng Jin, Wang Xiaoyong, Hao Bo, Shi Ruihua, Zhang Guoxin
Abstract excerpt
BACKGROUND: Studies on the association between MDM2 SNP309 (T > G) and gastric cancer have reported conflicting results. Thus, the aim of this study was to investigate whether MDM2 SNP309 is associated with susceptibility and prognosis of gastric carcinoma in Chinese patients. METHODS: Total of 574 gastric carcinoma cases and 574 age- and sex-matched healthy controls were included. MDM2 polymorphism was detected...
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