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Article

MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis.

PloS one - 1 Jan 2013

Ma Yong, Bian Jianmin, Cao Hongyong

Abstract excerpt

BACKGROUND: MDM2 is a major negative regulator of p53, and a single nucleotide polymorphism (SNP) in the MDM2 promoter region SNP309 has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including gastric cancer. Several studies were published to evaluate the association between SNP309 and gastric cancer risk. However, the results...

Topics

Case-Control Studies
Genetic Predisposition to Disease
Humans
Odds Ratio
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-mdm2
Stomach Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23451111
DOI: 10.1371/journal.pone.0056918
PMCID: PMC3581579

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis.PMID 23451111Read ↗

Meta-analysis of the MDM2 T309G polymorphism and gastric cancer risk.Semantic proximity Read ↗

Association between MDM2 SNP309 T>G and risk of gastric cancer: a meta-analysis.Semantic proximity Read ↗

Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients.Semantic proximity Read ↗

No association of MDM2 T309G polymorphism with susceptibility to Korean gastric cancer patients.Semantic proximity Read ↗

MDM2 oncogene, E3 ubiquitin protein ligase T309G polymorphism and risk of oesophageal or gastric cancer: meta-analysis of 15 studies.Semantic proximity Read ↗

MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis.Semantic proximity Read ↗

MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis.Semantic proximity Read ↗

Helicobacter pylori infection and MDM2 SNP309 association with gastric cancer susceptibility.Semantic proximity Read ↗

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