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Article

MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Sept 2006

Ohmiya Naoki, Taguchi Ayumu, Mabuchi Nobuyuki, Itoh Akihiro, Hirooka Yoshiki, Niwa Yasumasa, Goto Hidemi

Abstract excerpt

PURPOSE: Recently, a single-nucleotide polymorphism in the MDM2 promoter (SNP309) has been found to lower the age of onset of tumors and increase the occurrence of multiple primary tumors in Li-Fraumeni syndrome, and accelerate the development of sporadic adult soft tissue sarcoma. The aim of this study was to determine whether SNP309 is associated with susceptibility to gastric carcinoma and its prognosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16983111
DOI: 10.1200/JCO.2005.04.1459

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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