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Article

Meta-analysis of the MDM2 T309G polymorphism and gastric cancer risk.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014

Song Bo, Duan Zhong-Yu, Zhong Yun-Hua, Lei Na, Yang Yu-Qing, Luo Kai-Yuan

Abstract excerpt

BACKGROUND: Mdm2 binds to the amino-terminus of p53 to induce its degradation and a single nucleotide polymorphism in the MDM2 promoter region (T309G) has been reported to increase the risk of several carcinomas, such as gastric cancer. However, the results of published studies to analyze the association between MDM2 T309G and gastric cancer havve often conflicted. METHODS: To better illustrate the filiation...

Topics

Case-Control Studies
Genetic Predisposition to Disease
Humans
Polymorphism, Single Nucleotide
Prognosis
Proto-Oncogene Proteins c-mdm2
Risk Factors
Stomach Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24377582
DOI: 10.7314/apjcp.2013.14.11.6649

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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