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Article

Molecular changes in UV-induced and gamma-ray-induced mutations in human lymphoblastoid cells.

Mutation research - 1 Jun 1990

Tachibana A, Ohbayashi T, Takebe H, Tatsumi K

Abstract excerpt

We have characterized the structural changes in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene of 14 UV-induced, 15 gamma-ray-induced and 17 spontaneous mutants of human lymphoblastoid cells selected for 6-thioguanine (6TG) resistance. Southern blot analysis using the full-length HPRT cDNA as a probe revealed that 29% (5/17) of the spontaneous mutants contained detectable alterations in their...

Topics

Blotting, Southern
Cell Line
DNA
Drug Resistance
Gamma Rays
Genes
Humans
Hypoxanthine Phosphoribosyltransferase
Lymphocytes
Mutation
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thioguanine

Ultraviolet Rays

Source

Identifiers

PMID: 1973821
DOI: 10.1016/0027-5107(90)90053-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1973821-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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