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Article

Molecular characterization of hprt mutants induced by low- and high-LET radiations in human cells.

Mutation research - 1 Jan 1990

Whaley J M, Little J B

Abstract excerpt

Southern blotting techniques were employed to examine the spectrum of molecular alterations in DNA induced by internally emitting iodine isotopes and X-rays at and around the hprt locus in a human lymphoblastoid cell line. We analyzed 165 mutant clones using a cDNA probe for the human hprt locus,...

Topics

Animals
Blotting, Southern
Chromosome Deletion
DNA Probes
Dose-Response Relationship, Radiation
Energy Transfer
Genetic Linkage
Humans
Hypoxanthine Phosphoribosyltransferase
In Vitro Techniques
Iodine Radioisotopes
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Radiation Injuries, Experimental

X-Rays

Source

Identifiers

PMID: 2300083
DOI: 10.1016/0165-7992(90)90120-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2300083-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Molecular characterization of hprt mutants induced by low- and high-LET radiations in human cells.PMID 2300083Read ↗

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