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Article

Genome wide spontaneous mutation in human cells determined by the spectrum of mutations in hprt cDNA genes.

Mutagenesis - 1 May 1993

Lichtenauer-Kaligis E G, Thijssen J, den Dulk H, van de Putte P, Tasseron-de Jong J G, Giphart-Gassler M

Abstract excerpt

We have studied spontaneous mutagenesis in five hprt cDNA genes integrated at five different genomic positions in a human lymphoblastoid cell line (TK6). The spectra of 40 mutants from each position were combined to obtain a mutation spectrum of the overall genome. This collection of mutants was used to assess the contribution of several mutagenic processes to spontaneous mutagenesis. Deletions and single base...

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PMID: 8332083
DOI: 10.1093/mutage/8.3.207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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