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Article

Analysis of point mutations induced by ultraviolet light in human cells.

Mutation research - 1 Jul 1991

Keohavong P, Liu V F, Thilly W G

Abstract excerpt

Mutations induced in cultured human cells by 254-nm UV light were analyzed within exon 3 of the hypoxanthine guanine phosphoribosyl transferase (HPRT) gene. Five large independent cultures of human lymphoblastoid cells, line TK6, were exposed to 4 J/m2 of 254-nm UV light and mutants at the HPRT locus were selected en masse by 6-thioguanine (6TG) resistance. Exon 3 of the HPRT gene was amplified from the mutant...

Topics

Alleles
Autoradiography
Base Sequence
Electrophoresis, Polyacrylamide Gel
Exons
Hot Temperature
Humans
Hypoxanthine Phosphoribosyltransferase
Leukemia, Lymphoid
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Thioguanine

Tumor Cells, Cultured

Ultraviolet Rays

Source

Identifiers

PMID: 2067529
DOI: 10.1016/0027-5107(91)90141-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2067529-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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