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Article

Sequence analysis of X-ray-induced mutations occurring in a cDNA of the human hprt gene integrated into mammalian chromosomal DNA.

Radiation research - 1 May 1993

Kimura H, Higuchi H, Iyehara-Ogawa H, Kato T

Abstract excerpt

Sequences of 38 independent X-ray-induced mutations in a cDNA of the human hypoxanthine phosphoribosyltransferase (hprt) gene were analyzed after it was integrated into mammalian chromosomes as part of a shuttle vector. There were 15 base substitutions (39%), 9 frameshifts (24%), 11 deletions (29...

Topics

Animals
Base Sequence
Cell Line
Chromosomes
DNA
Humans
Hypoxanthine Phosphoribosyltransferase
Mice
Molecular Sequence Data
Mutation
Radiation Effects
Radiation Genetics

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PMID: 8488253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8488253-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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