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Article

Analysis of X-ray-induced HPRT mutations in CHO cells: insertion and deletions.

Mutation research - 1 Oct 1992

Fuscoe J C, Zimmerman L J, Fekete A, Setzer R W, Rossiter B J

Abstract excerpt

Molecular alterations were examined in the hypoxanthine guanine phosphoribosyltransferase (hprt) gene of 41 independent X-ray-induced thioguanine-resistant (TGR) Chinese hamster ovary (CHO) cell clones. Rapid screening of the clones by multiplex polymerase chain reaction (PCR) for the presence or absence of exons revealed that the causes of the mutant phenotype were total gene deletion (26/41), partial gene...

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PMID: 1383700
DOI: 10.1016/0027-5107(92)90198-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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