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Article

Molecular analysis of ultraviolet-induced mutations in a xeroderma pigmentosum cell line.

Journal of molecular biology - 20 Jan 1991

Dorado G, Steingrimsdottir H, Arlett C F, Lehmann A R

Abstract excerpt

We have isolated and characterized 47 ultraviolet light-induced hprt mutants from a simian virus 40-transformed excision-repair-deficient xeroderma pigmentosum cell line (complementation group A). Twenty-one independent mutations were found, of which the majority were point mutations. Eleven of these were identified as base changes, nine of which could be attributed to ultraviolet damage on the transcribed DNA...

Topics

Base Sequence
Cell Line
DNA Repair
Exons
Humans
Hypoxanthine Phosphoribosyltransferase
Molecular Sequence Data
Mutation
Oligonucleotides
Polymerase Chain Reaction
Ultraviolet Rays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Xeroderma Pigmentosum

Source

Identifiers

PMID: 1992158
DOI: 10.1016/0022-2836(91)90533-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1992158-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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