Article
Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2010
Quinn Julian M W, Tam Shanna, Sims Natalie A, Saleh Hasnawati, McGregor Narelle E, Poulton Ingrid J, Scott John W, Gillespie Matthew T, Kemp Bruce E, van Denderen B J W
Abstract excerpt
Since AMP-activated protein kinase (AMPK) plays important roles in modulating metabolism in response to diet and exercise, both of which influence bone mass, we examined the influence of AMPK on bone mass in mice. AMPK is an alphabetagamma heterotrimer where the beta subunit anchors the alpha catalytic and gamma regulatory subunits. Germline deletion of either AMPK beta1 or beta2 subunit isoforms resulted in...
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