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Article

Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models.

Biochemical Society transactions - 1 Feb 2003

Viollet B, Andreelli F, Jørgensen S B, Perrin C, Flamez D, Mu J, Wojtaszewski J F P, Schuit F C, Birnbaum M, Richter E, Burcelin R, Vaulont S

Abstract excerpt

AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid metabolism. To understand better the physiological role of the catalytic AMPK subunit isoforms, we generated two knockout mouse models with the alpha1 (AMPK alpha 1(-/-)) and alpha 2 (AMPK alpha 2(-/-)) catalytic subunit genes deleted. No defect in glucose homoeostasis was observed in AMPK alpha 1(-/-) mice. On the other hand,...

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Identifiers

PMID: 12546688
DOI: 10.1042/bst0310216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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