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Article

CCAAT/enhancer binding protein β-deficiency enhances type 1 diabetic bone phenotype by increasing marrow adiposity and bone resorption.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 May 2011

Motyl Katherine J, Raetz Michelle, Tekalur Srinivasan Arjun, Schwartz Richard C, McCabe Laura R

Abstract excerpt

Bone loss in type 1 diabetes is accompanied by increased marrow fat, which could directly reduce osteoblast activity or result from altered bone marrow mesenchymal cell lineage selection (adipocyte vs. osteoblast). CCAAT/enhancer binding protein beta (C/EBPβ) is an important regulator of both adipocyte and osteoblast differentiation. C/EBPβ-null mice have delayed bone formation and defective lipid accumulation in...

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Identifiers

PMID: 21346244
DOI: 10.1152/ajpregu.00764.2010
PMCID: PMC3094035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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