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Article

Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.

The EMBO journal - 17 Jun 2009

Smink Jeske J, Bégay Valérie, Schoenmaker Ton, Sterneck Esta, de Vries Teun J, Leutz Achim

Abstract excerpt

Disequilibrium between bone-forming osteoblasts and bone-resorbing osteoclasts is central to many bone diseases. Here, we show that dysregulated expression of translationally controlled isoforms of CCAAT/enhancer-binding protein beta (C/EBPbeta) differentially affect bone mass. Alternative translation initiation that is controlled by the mammalian target of rapamycin (mTOR) pathway generates long transactivating...

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Source

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Identifiers

PMID: 19440205
DOI: 10.1038/emboj.2009.127
PMCID: PMC2685610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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