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Article

AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation.

Biochimica et biophysica acta. Molecular cell research - 1 Dec 2017

Lin Hui, Ying Ying, Wang Yuan-Yuan, Wang Gang, Jiang Shan-Shan, Huang Deqinag, Luo Lingyu, Chen Ye-Guang, Gerstenfeld Louis C, Luo Zhijun

Abstract excerpt

Activin A receptor type I or activin receptor-like kinase 2 (ACVRI/ALK2) belongs to type I TGF-β family and plays an important role in bone development. Activating mutations of ALK2 containing the R206 to H mutation, are present in 95% in the rare autosomal genetic disease fibrodysplasia ossificans progressiva (FOP), which leads to the development of ectopic bone formation in muscle. The effect of AMP-activated...

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Identifiers

PMID: 28847510
DOI: 10.1016/j.bbamcr.2017.08.009
PMCID: PMC5660632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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