Article

Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle

2025-09-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical models of hyperglycemia. The regulatory AMPKγ subunit plays a central role in energy sensing. While the skeletal muscle-selective γ3 isoform is essential for AMP/ZMP-induced glucose uptake, it...

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Literature Corpus work: 72460ba3-43be-56ab-b484-0bae571687f6
DOI: 10.1101/2025.09.26.678768

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