Article

Contrasting effects of <i>Ksr2</i> , an obesity gene, on trabecular bone volume and bone marrow adiposity

2022-08-21

Abstract excerpt

Pathological obesity and its complications are associated with an increased propensity for bone fractures. Humans with certain genetic polymorphisms at the kinase suppressor of ras2 ( Ksr2 ) locus develop severe early-onset obesity and type 2 diabetes (T2D). Both conditions are phenocopied in mice with Ksr2 deleted, but whether this affects bone health remains unknown. Here we studied the bones of global Ksr2 n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fdaafa8d-0fc2-5560-a055-ae5364508a8d
DOI: 10.1101/2022.08.21.504689

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Contrasting effects of <i>Ksr2</i> , an obesity gene, on trabecular bone volume and bone marrow adiposityDOI 10.1101/2022.08.21.504689Read

Loss of <i>RREB1</i> reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytesSemantic proximity Read

KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel OxidationSemantic proximity Read

Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.Semantic proximity Read

Adipose-tissue derived signals control bone remodellingSemantic proximity Read

High-Fat Diet-Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice.Semantic proximity Read

Diet-Induced Metabolic Dysregulation in Female Mice Causes Osteopenia in Adult OffspringSemantic proximity Read

Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasisSemantic proximity Read

Human SH2B1 mutations are associated with maladaptive behaviors and obesity.Semantic proximity Read

A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis.Semantic proximity Read

Loss of BMPR2 leads to high bone mass due to increased osteoblast activitySemantic proximity Read

Loss of insulin receptor in osteoprogenitor cells impairs structural strength of bone.Semantic proximity Read

A disputed evidence on obesity: comparison of the effects of Rcan2(-/-) and Rps6kb1(-/-) mutations on growth and body weight in C57BL/6J mice.Semantic proximity Read