Article
Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo.
Journal of the American College of Cardiology - 1 Sept 2009
Wang Lei, Rao Fangwen, Zhang Kuixing, Mahata Manjula, Rodriguez-Flores Juan L, Fung Maple M, Waalen Jill, Cockburn Myles G, Hamilton Bruce A, Mahata Sushil K, O'Connor Daniel T
Abstract excerpt
OBJECTIVES: We asked whether naturally occurring genetic variation at the human NPY1R locus alters autonomic traits that might predispose individuals to cardiovascular disease. BACKGROUND: Neuropeptide Y (NPY) interacts with the Y(1) receptor, NPY1R, to control adrenergic activity and blood pressure (BP). METHODS: We searched for polymorphism at NPY1R by systematic resequencing in ethnically diverse people. There...
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