Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.

doi:10.1016/j.jacc.2008.07.047

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Article

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.

Journal of the American College of Cardiology - 28 Oct 2008

Chen Yuqing, Rao Fangwen, Rodriguez-Flores Juan L, Mahata Manjula, Fung Maple M, Stridsberg Mats, Vaingankar Sucheta M, Wen Gen, Salem Rany M, Das Madhusudan, Cockburn Myles G, Schork Nicholas J, Ziegler Michael G, Hamilton Bruce A, Mahata Sushil K, Taupenot Laurent, O'Connor Daniel T

Abstract excerpt

OBJECTIVES: We aimed to determine whether the common variation at the chromogranin A (CHGA) locus increases susceptibility to hypertension. BACKGROUND: CHGA regulates catecholamine storage and release. Previously we systematically identified genetic variants across CHGA. METHODS: We carried out dense genotyping across the CHGA locus in >1,000 individuals with the most extreme blood pressures (BPs) in the...

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Identifiers

PMID: 19017515
DOI: 10.1016/j.jacc.2008.07.047
PMCID: PMC2659417

Genes

CHGA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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