Article
Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects.
Human genetics - 1 Jan 2003
Knowles Joshua W, Erickson Laurie M, Guy Vanessa K, Sigel Carlie S, Wilder Jennifer C, Maeda Nobuyo
Abstract excerpt
Genetic susceptibility to common conditions, such as essential hypertension and cardiac hypertrophy, is probably determined by various combinations of small quantitative changes in the expression of many genes. NPR1, coding for natriuretic peptide receptor A (NPRA), is a potential candidate, because NPRA mediates natriuretic, diuretic, and vasorelaxing actions of the nariuretic peptides, and because genetically...
Topics
- Animals
- Aorta
- Cell Line
- DNA
- Dinucleotide Repeats
- Exons
- Genes, Reporter
- Genetic Variation
- Genome, Human
- Guanylate Cyclase
- Haplotypes
- Humans
- Introns
- Luciferases