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Article

Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs.

Journal of hypertension - 1 Jan 2013

Wei Zhiyun, Zhang Kuixing, Wen Gen, Balasubramanian Karthika, Shih Pei-an B, Rao Fangwen, Friese Ryan S, Miramontes-Gonzalez Jose P, Schmid-Schoenbein Geert W, Kim Hyung-Suk, Mahata Sushil K, O'Connor Daniel T

Abstract excerpt

OBJECTIVES: The neuropeptide Y(2) G-protein-coupled receptor (NPY2R) relays signals from PYY or neuropeptide Y toward satiety and control of body mass. Targeted ablation of the NPY2R locus in mice yields obesity, and studies of NPY2R promoter genetic variation in more than 10,000 human participants indicate its involvement in control of obesity and BMI. Here we searched for genetic variation across the human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23149563
DOI: 10.1097/HJH.0b013e32835b053d
PMCID: PMC3615981

Genes

PYY
SNAI1
DBP
FOXI1
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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