Article
Effects of rare and common blood pressure gene variants on essential hypertension: results from the Family Blood Pressure Program, CLUE, and Atherosclerosis Risk in Communities studies.
Circulation research - 18 Jan 2013
Nguyen Khanh-Dung H, Pihur Vasyl, Ganesh Santhi K, Rakha Ankit, Cooper Richard S, Hunt Steven C, Freedman Barry I, Coresh Joe, Kao W H Linda, Morrison Alanna C, Boerwinkle Eric, Ehret Georg B, Chakravarti Aravinda
Abstract excerpt
RATIONALE: Hypertension affects ≈30% of adults in industrialized countries and is the major risk factor for cardiovascular disease. OBJECTIVE: We sought to study the genetic effect of coding and conserved noncoding variants in syndromic hypertension genes on systolic blood pressure (BP) and diastolic BP to assess their overall impact on essential hypertension. METHODS AND RESULTS: We resequenced 11 genes (AGT,...
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