Article
The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.
Human molecular genetics - 1 Jan 2018
Ren Meixia, Ng Fu Liang, Warren Helen R, Witkowska Kate, Baron Michael, Jia Zhilong, Cabrera Claudia, Zhang Ruoxin, Mifsud Borbala, Munroe Patricia B, Xiao Qingzhong, Townsend-Nicholson Andrea, Hobbs Adrian J, Ye Shu, Caulfield Mark J
Abstract excerpt
Elevated blood pressure (BP) is a major global risk factor for cardiovascular disease. Genome-wide association studies have identified several genetic variants at the NPR3 locus associated with BP, but the functional impact of these variants remains to be determined. Here we confirmed, by a genome-wide association study within UK Biobank, the existence of two independent BP-related signals within NPR3 locus....
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