Article
Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population.
Circulation. Cardiovascular genetics - 1 Dec 2017
Salo Perttu P, Havulinna Aki S, Tukiainen Taru, Raitakari Olli, Lehtimäki Terho, Kähönen Mika, Kettunen Johannes, Männikkö Minna, Eriksson Johan G, Jula Antti, Blankenberg Stefan, Zeller Tanja, Salomaa Veikko, Kristiansson Kati, Perola Markus
Abstract excerpt
BACKGROUND: Cardiomyocytes secrete atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in response to mechanical stretching, making them useful clinical biomarkers of cardiac stress. Both human and animal studies indicate a role for ANP as a regulator of blood pressure with conflicting results for BNP. METHODS AND RESULTS: We used genome-wide association analysis (n=6296) to study the effects of...
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