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Article

Genetic variation in human NPY expression affects stress response and emotion.

Nature - 24 Apr 2008

Zhou Zhifeng, Zhu Guanshan, Hariri Ahmad R, Enoch Mary-Anne, Scott David, Sinha Rajita, Virkkunen Matti, Mash Deborah C, Lipsky Robert H, Hu Xian-Zhang, Hodgkinson Colin A, Xu Ke, Buzas Beata, Yuan Qiaoping, Shen Pei-Hong, Ferrell Robert E, Manuck Stephen B, Brown Sarah M, Hauger Richard L, Stohler Christian S, Zubieta Jon-Kar, Goldman David

Abstract excerpt

Understanding inter-individual differences in stress response requires the explanation of genetic influences at multiple phenotypic levels, including complex behaviours and the metabolic responses of brain regions to emotional stimuli. Neuropeptide Y (NPY) is anxiolytic and its release is induced by stress. NPY is abundantly expressed in regions of the limbic system that are implicated in arousal and in the...

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Identifiers

PMID: 18385673
DOI: 10.1038/nature06858
PMCID: PMC2715959

Genes

NPY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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