Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.

doi:10.1016/j.jacc.2012.06.042

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.

Journal of the American College of Cardiology - 23 Oct 2012

Zhang Kuixing, Rao Fangwen, Miramontes-Gonzalez Jose Pablo, Hightower C Makena, Vaught Brian, Chen Yuhong, Greenwood Tiffany A, Schork Andrew J, Wang Lei, Mahata Manjula, Stridsberg Mats, Khandrika Srikrishna, Biswas Nilima, Fung Maple M, Waalen Jill, Middelberg Rita P, Heath Andrew C, Montgomery Grant W, Martin Nicholas G, Whitfield John B, Baker Dewleen G, Schork Nicholas J, Nievergelt Caroline M, O'Connor Daniel T

Abstract excerpt

OBJECTIVES: This study sought to understand whether genetic variation at the Neuropeptide Y (NPY) locus governs secretion and stress responses in vivo as well as NPY gene expression in sympathochromaffin cells. BACKGROUND: The NPY is a potent pressor peptide co-released with catecholamines during stress by sympathetic axons. Genome-wide linkage on NPY secretion identified a LOD (logarithm of the odds ratio) peak...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to Gene Expression Regulation

Share to Hypertension

Share to Neuropeptide Y

Share to Promoter Regions, Genetic

Share to Receptors, Glucocorticoid

Share to Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 23021333
DOI: 10.1016/j.jacc.2012.06.042
PMCID: PMC3687554

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.PMID 23021333Read ↗

Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo.Semantic proximity Read ↗

Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y(2) receptor promoter disrupt multiple transcriptional response motifs.Semantic proximity Read ↗

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.Semantic proximity Read ↗

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.Semantic proximity Read ↗

Adrenergic polymorphism and the human stress response.Semantic proximity Read ↗

Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo.Semantic proximity Read ↗

Genetic variation in human NPY expression affects stress response and emotion.Semantic proximity Read ↗

Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure.Semantic proximity Read ↗

Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.Semantic proximity Read ↗

Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach.Semantic proximity Read ↗

Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.Semantic proximity Read ↗

MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertensionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.