Article
Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2009
Berman Seth D, West Julie C, Danielian Paul S, Caron Alicia M, Stone James R, Lees Jacqueline A
Abstract excerpt
The retinoblastoma tumor-suppressor protein, pRb, is a member of the pocket protein family that includes p107 and p130. These proteins have well-defined roles in regulating entry into and exit from the cell cycle and also have cell cycle-independent roles in facilitating differentiation. Here we investigate the overlap between pocket protein's function during embryonic development by using conditional mutant...
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