Retinoblastoma Family Proteins Have Distinct Functions in Pulmonary Epithelial Cells <i>In vivo</i> Critical for Suppressing Cell Growth and Tumorigenesis

Abstract excerpt

Lung cancer is the leading cause of cancer deaths, accounting for more deaths than breast, colon, and prostate cancer combined. The retinoblastoma (Rb)/p16 tumor suppressive pathway is deregulated in most cancers. Loss of p16 occurs more frequently than Rb loss, suggesting that p16 suppresses cancer by regulating Rb as well as the related proteins p107 and p130. However, direct evidence demonstrating that p130 or...

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