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Insights from mouse models into human retinoblastoma

1 Jan 2008

Abstract excerpt

Novel murine models of retinoblastoma based on Rb gene deletion in concert with inactivation of Rb family members have recently been developed. These new Rb knockout models of retinoblastoma provide excellent tools for pre-clinical studies and for the exploration of the genetics of tumorigenesis driven by RB inactivation. This review focuses on the developmental consequences of Rb deletion in the retina and the...

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PMID: 18489754
DOI: 10.1186/1747-1028-3-9

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