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Article

Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation.

Oncogene - 1 Oct 2013

Landman A S, Danielian P S, Lees J A

Abstract excerpt

The pocket proteins pRB, p107 and p130 have established roles in regulating the cell cycle through the control of E2F activity. The pocket proteins regulate differentiation of a number of tissues in both cell cycle-dependent and -independent manners. Prior studies showed that mutation of p107 and p130 in the mouse leads to defects in cartilage development during endochondral ossification, the process by which...

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Identifiers

PMID: 23146901
DOI: 10.1038/onc.2012.496
PMCID: PMC3931423

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Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation.PMID 23146901Read ↗

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