Article
Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb.
Molecular and cellular biology - 1 Mar 2005
MacLellan W R, Garcia A, Oh H, Frenkel P, Jordan M C, Roos K P, Schneider M D
Abstract excerpt
The pocket protein family of tumor suppressors, and Rb specifically, have been implicated as controlling terminal differentiation in many tissues, including the heart. To establish the biological functions of Rb in the heart and overcome the early lethality caused by germ line deletion of Rb, we used a Cre/loxP system to create conditional, heart-specific Rb-deficient mice. Mice that are deficient in Rb...
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