Article
Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene.
Development (Cambridge, England) - 1 Dec 1998
LeCouter J E, Kablar B, Whyte P F, Ying C, Rudnicki M A
Abstract excerpt
The retinoblastoma-related p130 protein is a member of a conserved family, consisting of Rb, p107 and p130, which are believed to play important roles in cell-cycle control and cellular differentiation. We have generated a null mutation in p130 by gene targeting and crossed the null allele into B...
Topics
- Animals
- Apoptosis
- Crosses, Genetic
- Embryo, Mammalian
- Embryonic and Fetal Development
- Female
- Fetal Death
- Gestational Age
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Phosphoproteins
- Pregnancy
- Proteins
- Retinoblastoma Protein