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Article

Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development.

The EMBO journal - 1 Jul 2002

Ferguson Kerry L, Vanderluit Jacqueline L, Hébert Jean M, McIntosh W C, Tibbo Emma, MacLaurin Jason G, Park David S, Wallace Valerie A, Vooijs Marc, McConnell Susan K, Slack Ruth S

Abstract excerpt

Correct cell cycle regulation and terminal mitosis are critical for nervous system development. The retinoblastoma (Rb) protein is a key regulator of these processes, as Rb-/- embryos die by E15.5, exhibiting gross hematopoietic and neurological defects. The extensive apoptosis in Rb-/- embryos has been attributed to aberrant S phase entry resulting in conflicting growth control signals in differentiating cells....

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Identifiers

PMID: 12093735
DOI: 10.1093/emboj/cdf338
PMCID: PMC126087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development.PMID 12093735Read ↗

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