Article
Retinoblastoma family proteins: insights gained through genetic manipulation of mice.
Cellular and molecular life sciences : CMLS - 1 Apr 2006
Wikenheiser-Brokamp K A
Abstract excerpt
The retinoblastoma (Rb) gene was identified as the first tumor suppressor gene two decades ago. Since this initial discovery, it has become clear that deregulated Rb function constitutes a hallmark of human malignancies. Rb is a well-established regulator of the cell cycle. Rb has also been implicated in playing a role in a wide variety of cellular processes including DNA repair, cellular senescence, cell fate...
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