Article
Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.
Molecular and cellular biology - 1 Jul 2007
Yeh Nancy, Miller Jeffrey P, Gaur Tripti, Capellini Terence D, Nikolich-Zugich Janko, de la Hoz Carmen, Selleri Licia, Bromage Timothy G, van Wijnen Andre J, Stein Gary S, Lian Jane B, Vidal Anxo, Koff Andrew
Abstract excerpt
Pocket proteins and cyclin-dependent kinase (CDK) inhibitors negatively regulate cell proliferation and can promote differentiation. However, which members of these gene families, which cell type they interact in, and what they do to promote differentiation in that cell type during mouse development are largely unknown. To identify the cell types in which p107 and p27 interact, we generated compound mutant mice....
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