Article
Rb family proteins differentially regulate distinct cell lineages during epithelial development.
Development (Cambridge, England) - 1 Sept 2004
Wikenheiser-Brokamp Kathryn A
Abstract excerpt
pRb, p107 and p130 are important regulators of cell cycle and have extensive overlapping functions; however, only Rb has been shown to be a bone fide tumor suppressor. Defining the overlapping versus distinct pocket protein functions is therefore an important step to understanding the unique role of Rb. Using lung as a model, the present studies demonstrate that pocket proteins are important not only in...
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