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Article

Bcr and Abr cooperate in negatively regulating acute inflammatory responses.

Molecular and cellular biology - 1 Nov 2009

Cunnick Jess M, Schmidhuber Sabine, Chen Gang, Yu Min, Yi Sun-Ju, Cho Young Jin, Kaartinen Vesa, Minoo Parviz, Warburton David, Groffen John, Heisterkamp Nora

Abstract excerpt

Bcr and Abr are GTPase-activating proteins for the small GTPase Rac. Both proteins are expressed in cells of the innate immune system, including neutrophils and macrophages. The function of Bcr has been linked to the negative regulation of neutrophil reactive oxygen species (ROS) production, but the function of Abr in the innate immune system was unknown. Here, we report that mice lacking both proteins are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19703997
DOI: 10.1128/MCB.00357-09
PMCID: PMC2772743

Genes

MMP9
MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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