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Article

Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.

Molecular and cellular biology - 1 Feb 2007

Cho Young Jin, Cunnick Jess M, Yi Sun-Ju, Kaartinen Vesa, Groffen John, Heisterkamp Nora

Abstract excerpt

Small GTPases of the Rho family are key regulators of phagocytic leukocyte function. Abr and Bcr are homologous, multidomain proteins. Their C-terminal domain has GTPase-activating protein (GAP) activity that, in vitro, is specific for Rac and Cdc42. To address the in vivo relevance of these entire proteins, of which little is known, the current study examined the effect of the genetic ablation of Abr and Bcr in...

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Identifiers

PMID: 17116687
DOI: 10.1128/MCB.00756-06
PMCID: PMC1800684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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