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Article

MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.

PloS one - 1 Jan 2012

González-López Adrián, Aguirre Alina, López-Alonso Inés, Amado Laura, Astudillo Aurora, Fernández-García María Soledad, Suárez María F, Batalla-Solís Estefanía, Colado Enrique, Albaiceta Guillermo M

Abstract excerpt

Matrix metalloproteinase-8, released mainly from neutrophils, is a critical regulator of the inflammatory response by its ability to cleave multiple mediators. Herein, we report the results of a model of endotoxemia after intraperitoneal LPS injection in mice lacking MMP-8 and their wildtype counterparts. Control, saline-treated animals showed no differences between genotypes. However, there was an increased lung...

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Identifiers

PMID: 22768176
DOI: 10.1371/journal.pone.0039940
PMCID: PMC3386945

Genes

MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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