Article

FcγRIIIb-deficient neutrophils have defects in ROS production, phagocytosis and actin polymerization following stimulation through FcγRs

2025-05-09

Abstract excerpt

Neutrophils are crucial to innate immune responses to microbes. The crosslinking of opsonized pathogens by Fc gamma receptors (FcγRs) on neutrophil surfaces mediates multiple antimicrobial functions, including phagocytosis and the production of reactive oxygen species (ROS). FcγRIIIb (CD16b) is the most abundant receptor on human neutrophils. It is a GPI-anchored receptor that lacks an intracellular domain. The ex...

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Literature Corpus work: 5ae8945d-4b7d-530d-a7b9-529d31c54329
DOI: 10.1101/2025.05.08.25327271

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