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Article

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance

25 Aug 2017

Abstract excerpt

Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent and severe bacterial infections, while their unregulated release leads to pathology from excessive inflammation. The release of high concentrations of ROS aids in clearance of invading bacteria. Localization of ROS release to phagosomes...

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Share to Immune Response and Inflammation
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 28890882
DOI: 10.3389/fcimb.2017.00373

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